Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes |
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| Authors: | Ben M Minogue Stephen M Richardson Leo AH Zeef Anthony J Freemont Judith A Hoyland |
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| Affiliation: | (1) Tissue Injury and Repair, Faculty of Medical and Human Sciences, School of Biomedicine, University of Manchester, Oxford Road, Manchester, M13 9PT, UK;(2) Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK |
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| Abstract: | Introduction Nucleus pulposus (NP) cells have a phenotype similar to articular cartilage (AC) cells. However, the matrix of the NP is clearly different to that of AC suggesting that specific cell phenotypes exist. The aim of this study was to identify novel genes that could be used to distinguish bovine NP cells from AC and annulus fibrosus (AF) cells, and to further determine their expression in normal and degenerate human intervertebral disc (IVD) cells. |
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