Reaction of S-nitrosoglutathione with sulfhydryl groups in protein |
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Authors: | J W Park |
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Institution: | Department of Biochemistry, Ohio State University, Columbus 43210. |
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Abstract: | The covalent modification of sulfhydryl groups by S-nitrosoglutathione has been examined using model compounds. S-Nitrosoglutathione and thiol compounds causing extremely fast transnitrosation reaction and subsequent production of mixed disulfide. Yeast alcohol dehydrogenase is rapidly inactivated by S-nitrosoglutathione. The reversibility and Ellman test demonstrate that the inactivation is the result of covalent modification of sulfhydryl groups in this enzyme. |
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