TRP channels as target sites for insecticides: physiology,pharmacology and toxicology |
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Authors: | Keiichi Nagata |
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Institution: | (1) Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA |
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Abstract: | Transient receptor potential (TRP) channels are attracting attention from various research areas including physiology, pharmacology
and toxicology. Our group has focused on TRPA1 channels and revealed their expression pattern, ion channel kinetics and pharmacological
characteristics. From Integrated Pest Management point of view, TRP channels could be a possible new target site of pest control
agents as well as the primary or secondary target site for known insecticides. We have examined expressed TRPA1 channels using
physiological and pharmacological methods to clarify the function of these channels. Here, we show that the TRPA1 is activated
by the insecticide and natural toxin allyl isothiocyanate which is known as insecticide. |
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Keywords: | TRP channel Transient receptor potential channel Allyl isothiocyanate Patch-clamp Toxicology Pharmacology |
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