Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations |
| |
Authors: | Pravitt Gourh Frank C Arnett Shervin Assassi Filemon K Tan Mei Huang Laura Diekman Maureen D Mayes John D Reveille Sandeep K Agarwal |
| |
Institution: | (1) Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, 6431 Fannin M.S.B. 5.278, Houston, TX 77030, USA |
| |
Abstract: | Introduction Systemic sclerosis (SSc) (scleroderma) is a complex autoimmune disease that clinically manifests as progressive fibrosis of
the skin and internal organs. Anti-centromere antibodies (ACAs), anti-topoisomerase antibodies (ATAs), and anti-RNA polymerase
III antibodies (ARAs) are three mutually exclusive SSc-associated autoantibodies that correlate with distinct clinical subsets
characterized by extent of cutaneous involvement and pattern of organ involvement. The current report sought to determine
whether plasma cytokine profiles differ in SSc patients grouped according to these SSc-associated autoantibody subsets. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|