Role of impaired DNA repair in genotoxic susceptibility of patients with head and neck cancer |
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| Authors: | Pawel Rusin Jurek Olszewski Alina Morawiec-Bajda Karolina Przybylowska Dariusz Kaczmarczyk Aleksandra Golinska Ireneusz Majsterek |
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| Institution: | (1) Department of Molecular Genetics, University of Lodz, Banacha 12/16 Street, 90-237 Lodz, Poland;(2) Department of Otolaryngology and Oncology, Medical University of Lodz, Lodz, Poland;(3) Department of Head and Neck Cancer, Medical University of Lodz, Lodz, Poland;(4) Department of Chronopharmacology, Medical University of Lodz, Lodz, Poland; |
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| Abstract: | DNA repair is critical for genotoxic susceptibility and cancer development. Forty-seven patients with head and neck squamous
cell carcinoma (HNSCC) and 38 healthy controls were enrolled in this study. Among the patients, 16 subjects had metastasis
of HNSCC. The extent of DNA damage, including oxidative lesions, and efficiency of repair after genotoxic treatment with hydrogen
peroxide were examined using the alkaline comet assay. HNSCC cells were sensitive to genotoxic treatment and displayed impaired
DNA repair. In particular, lesions caused by hydrogen peroxide were repaired less effectively in cancer cells from patients
with metastasis than in cells from healthy controls. We suggest that impaired DNA repair might play a role in genotoxic susceptibility
of patients with head and neck cancer. Finally, as a consequence of this finding we have shown that treatment with DNA-reactive
drugs could be considered as an effective therapy strategy for head and neck cancer. |
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