A two-backbone polymer model for interphase chromosome geometry |
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| Authors: | Bing Liu Rainer K. Sachs |
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| Affiliation: | (1) Department of Mathematics, College of St. Scholastica, 55811 Duluth, MN, U.S.A.;(2) Department of Mathematics, University of California, 94720 Berkeley, CA, U.S.A. |
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| Abstract: | A polymer model for the overall geometric structure of a human chromosome during the G0/G1 portion of cell-cycle interphase is constructed, based on fluorescencein situ hybridization data on distances between defined genomic sequences. The model consists of flexible giant loops, averaging about 6 million base pairs, with two random-walk backbones; it involves essentially three parameters. Numerical results based on properly selected values of parameters fit the data well. |
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