Neurological disorder and excessive accumulation of calcium in brain of clinically vitamin A-deficient rats |
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Authors: | Ahmed S Rahman Mieko Kimura Katsuhiko Yokoi Tanvir-E Naher Yoshinori Itokawa |
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Institution: | (1) Department of Social Medicine, Graduate School of Medicine, Kyoto University, Sakyo-Ku, 606-01 Kyoto, Japan |
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Abstract: | Three groups of rats were fed two types of synthetic diets for 52 d. The—A group was allowed free access to a vitamin A-deficient
diet and showed classical signs of vitamin A deficiency. The brain was the only organ in our experiment where no significant
weight difference was present among the three groups. In the brain, calcium concentration was significantly higher in the—A
group when compared with the PF (Pair-fed; allowed restricted amount of control diet) and +A groups (allowed free access to
control diet). In the tibia, calcium and magnesium concentrations were significantly lower in the—A group when compared with
other two groups. Excessive accumulation of calcium in brain and apparently similar unbalance in bone, mineral concentration
were observed in central nervous system (CNS) degenerative diseases. Our results suggest that abnormal metabolism of calcium
and magnesium in some tissues and excessive accumulation of calcium in brain may be responsible for the development of neurological
disorders in vitamin A-deficient rats. |
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Keywords: | Rats vitamin A deficiency neurological disorder calcium accumulation in brain mineral tissues |
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