Genetic Evidence for Preferential Strand Transfer during Meiotic Recombination in Yeast |
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| Authors: | D K Nag and T D Petes |
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| Institution: | Department of Biology, University of North Carolina, Chapel Hill 27599-3280. |
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| Abstract: | During meiotic recombination in the yeast Saccharomyces cerevisiae, heteroduplexes are formed as an intermediate in the exchange process. In the formation of an asymmetric heteroduplex, one chromosome acts as a donor of a single DNA strand and the other acts as a recipient. We present genetic evidence that the nontranscribed strand is donated more frequently than the transcribed strand in spores that have an unrepaired mismatch at the HIS4 locus. |
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