IL-2-dependent generation of natural killer cells from bone marrow: role of MAC-1-, NK1-1- precursors. |
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| Authors: | G Migliorati R Moraca I Nicoletti C Riccardi |
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| Institution: | Institute of Pharmacology, School of Medicine, University of Perugia, Italy. |
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| Abstract: | We have previously shown that interleukin-2 (IL-2) is able to induce the generation of natural killer (NK) activity in bone marrow (BM) cell cultures from mice pretreated with 5-fluorouracil (5-FU). Cell fractionation experiments to analyze the nature of BM precursors indicate that MAC-1-, NK1-1- noncytotoxic precursors are induced by IL-2 to proliferate and generate cytolytic NK cells. These data demonstrate that the phenotype and functional characteristics of the IL-2-responsive cells in the FUBM are different from those of mature NK cells in that they are MAC-1+, NK1.1+, CD3- and susceptible to boosting by IFN-alpha. |
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