Enterostatin (APGPR) enhances memory consolidation in mice |
| |
Authors: | Ohinata Kousaku Sonoda Soushi Shimano Tomoko Yoshikawa Masaaki |
| |
Institution: | Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto 611-0011, Japan. |
| |
Abstract: | Enterostatin (APGPR) is a pentapeptide released from its precursor protein, procolipase. We found for the first time that enterostatin has memory-enhancing activity. Enterostatin enhanced memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice. The memory-enhancing activity of enterostatin was inhibited by pretreatment with lorglumide, an antagonist for cholecystokinin 1 (CCK1) receptor. However, enterostatin had no affinity for CCK receptors. These results suggest that enterostatin improves memory retention through CCK release. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|