miR-181a mediates metabolic shift in colon cancer cells via the PTEN/AKT pathway |
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Affiliation: | 1. Department of Pathology of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, China;2. Department of Colorectal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, China;3. Department of Biochemistry & Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China |
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Abstract: | Cancer cell metabolism is often characterized by a shift from an oxidative to a glycolytic bioenergetics pathway, a phenomenon known as the warburg effect. Whether the deregulation of miRNAs contributes to the warburg effect remains largely unknown. Here we show that miR-181a expression is increased and thus induces a metabolic shift in colon cancer cells. miR-181a performs this function by inhibiting the expression of PTEN, leading to an increase of phosphorylated AKT which triggers metabolic shift. The increase of lactate production induced by miR-181a results in the rapid growth of cancer cells. These results identify miR-181a as a molecular switch involved in the orchestration of the warburg effect in colon cancer cells via the PTEN/AKT pathway. |
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Keywords: | miR-181a PTEN Glycolysis |
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