Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents |
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| Authors: | Chun Byoung-Kwon Wang Peiyuan Hassan Abdalla Du Jinfa Tharnish Phillip M Murakami Eisuke Stuyver Lieven Otto Michael J Schinazi Raymond F Watanabe Kyoichi A |
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| Affiliation: | Pharmasset, Inc., Princeton, New Jersey 08540, USA. kwon.chun@pharmasset.com |
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| Abstract: | In order to study structure-activity relationships among the derivatives and congeners of 5',9-anhydro-3-(beta-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5',9-anhydro-purine-isonucleosides with a substituent (s) at 6- or/and 8-position of the purine moiety were synthesized, and their anti-hepatitis C virus activity and cytotoxicity were evaluated and discussed. |
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