Distamycin A-DAPI banding of nonfluorescent Y (Ynf) chromosomes in 45,X/46,XYnf mosaicism |
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| Authors: | Lawrence P Wisniewski Kurt Hirschhorn |
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| Institution: | (1) Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 14642 Rochester, NY, USA;(2) Department of Pediatrics, Mount Sinai School of Medicine, 10029 New York, NY, USA |
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| Abstract: | Summary The distamycin A-DAPI banding patterns of nonfluorescent, nonheterochromatic Y chromosomes (Ynf) in two patients with 45,X/46,XYnf mosaicism were investigated. In both cases moderately fluorescent bands were observed near the centromere and on the distal long arm of the Ynf. These bands were similar to the centrometric band on normal Y chromosomes and support the hypothesis that the Ynf is an isodicentric chromosome derived from the proximal portion of the Y chromosome. |
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