Effects of autologous stem cell transplantation on ventricular electrophysiology in doxorubicin-induced heart failure |
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Authors: | Chen Mao Fan Zhong-Cai Liu Xiao-Jing Deng Jue-Lin Zhang Li Rao Li Yang Qing Huang De-Jia |
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Institution: | Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. hmaochen@vip.sina.com |
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Abstract: | To investigate whether stem cell transplantation affects ventricular electrophysiology in vivo, either autologous bone marrow mesenchymal stem cells or skeletal myoblast cells were transplanted via a catheter into a doxorubicin-treated failing heart. Four weeks after transplantation, electrophysiological investigation showed that transplantation of either cell type prolonged the local activation time and increased the activation time dispersion. In the stem cell transplantation groups, a positive correlation was demonstrated between activation time dispersion and the number of stem cell-derived cells in the pacing site. It is concluded that transplantation of either mesenchymal stem cells or skeletal myoblast cells might exacerbate abnormalities of local ventricular conduction in the doxorubicin-treated failing heart. |
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Keywords: | Stem cells Transplantation Heart failure Electrophysiology Conduction |
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