Beneficial actions of prostacyclin in traumatic shock |
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| Authors: | Allan M. Lefer Steven L. Sollott Michael J. Galvin |
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| Affiliation: | Department of Physiology Jefferson Medical College of Thomas Jefferson University Philadelphia, Pennsylvania 19107, USA |
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| Abstract: | Prostacyclin (PGI2) infused at a rate of 350 ng/kg/min significantly increased survival time in rats subjected to Noble-Collip drum trauma from 2.7±0.3 to 4.6±0.2 h (p<0.01) compared with traumatized rats given only the vehicle (Tris buffer). Moreover, PGI2 treated rats exhibited significantly lower circulating cathepsin D and myocardial depressant factor (MDF) activities, indicative of lower lysosomal disruption and lower toxic factor formation. PGI2 induced vasodilation in rats as well as these other protective effects. |
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