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Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability
Institution:1. Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China;2. Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518005, People’s Republic of China;3. Department of Biology, School of Life Sciences, Brain Research Center, Southern University of Science and Technology, Shenzhen 518000, People’s Republic of China
Abstract:
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  • Keywords:Rheb  mTORC1  Schwann cells  peripheral axons  axon degeneration  metabolic coupling  pyruvate metabolism  lactate shuttle  oxidative stress  ROS
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