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Senescent immune cells release grancalcin to promote skeletal aging
Affiliation:1. Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China;2. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan 410008, China;3. Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Hunan 410008, China;4. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;5. University of Chinese Academy of Sciences, Beijing 100049, China;6. Aging Translational Medicine Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Abstract:
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  • Keywords:grancalcin  immune cells  skeletal aging  bone marrow mesenchymal stromal cells  plexin-b2 pathway  immunoregulation  bone remodeling  linage fate  senescence
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