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H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
Affiliation:1. Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA;2. Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA;3. Department of Vascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, China;4. Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA;5. Internal Medicine, Cardiovascular Medicine Section, Yale Cardiovascular Research Center, Yale University, New Haven, CT, USA;6. Department of Pharmacology, Yale University, New Haven, CT, USA;7. Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;8. Center for Microvascular Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;9. Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA
Abstract:
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  • Keywords:epigenetics  gene regulation  cell differentiation  histone modifications  DNA methylation  microRNA  vascular injury  vascular disease
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