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Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors
Affiliation:1. Gilbert Family Neurofibromatosis Institute, Children’s National Hospital, Washington, DC 20010, USA;2. Center for Cancer and Immunology Research, Children’s National Hospital, Washington, DC 20010, USA;3. Center for Neuroscience Research, Children’s National Hospital, Washington, DC 20010, USA;4. Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA;5. Center for Genetic Medicine Research, Children’s National Hospital, Washington, DC 20010, USA;6. Retinal Neurophysiology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA;7. Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA;8. GW Cancer Center, George Washington University, Washington, DC 20052
Abstract:
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  • Keywords:Neurofibromatosis type 1  NF1  optic pathway glioma (OPG)  pilocytic astrocytoma  pediatric low-grade glioma  neural stem cells  hypothalamic ventricular zone radial glia  hVZ-RG  hypothalamic mantle zone radial glia  hMZ-RG
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