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DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing
Institution:1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China;4. Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China;5. Fudan Institute for Metabolic Diseases, Shanghai 200032, China;6. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China;7. Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
Abstract:
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  • Keywords:hepatic steatosis  nonalcoholic fatty liver disease  RNA alternative splicing  mitochondrial function  mtDNA  Drak2  serine/arginine-rich splicing factor (SRSF)
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