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Tumor-derived MMPs regulate cachexia in a Drosophila cancer model
Institution:1. Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia;2. Sir Peter MacCallum Department of Oncology, the University of Melbourne, Melbourne, VIC 3000, Australia;3. Department of Anatomy and Physiology, the University of Melbourne, Melbourne, VIC 3000, Australia;4. Centre for Dynamic Imaging, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia;5. Division of Immunology, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia;6. Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia;7. Department of Biochemistry & Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia
Abstract:
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  • Keywords:cachexia  interorgan crosstalk  fat body  muscle  TGFβ signaling  MMP  Timp
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