Liposomes as delivery agents for medical imaging |
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| Affiliation: | 1. School of Computer and Information, Hefei University of Technology, Hefei 230009, China;2. School of Electronic and Computer Engineering, Peking University Shenzhen Graduate School, Shenzhen 518055, China;1. Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China;2. Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zunyi Medical University Zhuhai Campus, Zhuhai 519041, China;1. Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan;2. Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53711, USA;3. Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan;4. Transboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan;5. Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan;6. Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation, Osaka, Japan;7. Laboratory of Vaccine Science, IFReC, Osaka University, Osaka, Japan;8. ERATO Infection-Induced Host Responses Project (JST), Saitama 332-0012, Japan;9. Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan |
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| Abstract: | Medical imaging requires an appropriate intensity of signal from the area of interest in order to differentiate certain structures from surrounding tissues, regardless of the modality used. In the majority of cases, contrast agents specific for each imaging modality are necessary to achieve a sufficiently intense signal. To facilitate the accumulation of contrast in the required zone, various microparticulates have been suggested as carriers for contrast agents. Among these carriers, liposomes - microscopic artificial phospholipid vesicles - draw special attention because of their easily controlled properties and useful pharmacological characteristics. This review will discuss how the advantages of liposomes have been used so far in the rapidly growing field of diagnostic medical imaging. |
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