Integrin adhesion receptors: structure,function and implications for biomedicine |
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| Institution: | 1. Assistant Professor, Bingol University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bingol, Turkey;2. Associate Professor, Istanbul Kent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Istanbul, Turkey.;1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan;2. Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh;3. Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh;4. University of the Philippines Visayas Tacloban College, Tacloban City 6500, Philippines;1. Department of Chemistry, Kansas State University, 1212 Mid-Campus Drive North, 203 CBC Building, Manhattan, KS 66506, United States;2. Department of Biochemistry, Kansas State University, 1711 Claflin Road, Manhattan, KS 66506, United States;3. Department of Statistics, Kansas State University, 101 Dickens Hall, Manhattan, KS 66506, United States;1. Department of Functional Molecular Biology, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan;2. Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh;1. Department of Critical Care Medicine, Children’s Hospital of Pittsburgh, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;2. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA |
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| Abstract: | Over the past decade, multi-disciplinary approaches have led to the discovery and characterization of several classes of adhesion molecules. Under normal conditions, these molecules provide support for cells, regulate cell migration and contain information that cells use when sensing their environment. In disease, adhesive function is frequently compromised and results in tissue disorder, aberrant cell migration and dysregulation of signalling pathways. The integrins are a major family of adhesion receptors produced by most cell types and are a means by which the cell senses its immediate environment and responds to changes in extracellular matrix composition. Recent years have seen major advances in our understanding of integrin-ligand interactions, and have revealed a structurally dynamic family of receptors capable of translating information into and out of the cell. |
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