Neurotrophin receptors,tumor progression and tumor maturation |
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| Institution: | 1. School of Law, University of Canterbury, Christchurch, New Zealand;2. Soul Machines, Auckland, New Zealand;3. Department of Computer Science, University of Kentucky, Lexington, USA;1. Department of Pharmacology, UCL School of Pharmacy, 29-39 Brunswick Square, Bloomsbury, London WC1N 1AX, UK;2. UCL Centre for Nerve Engineering, London, UK;3. Peripheral Nerve Injury Unit Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, London, UK |
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| Abstract: | The nerve growth factor receptor TrkA was initially isolated as a transforming oncogene, trk, in which most of the extracellular receptor part is replaced by the coding sequence for a tropomyosin-encoding gene. The impact that the identification of the first neurotrophin receptor has made on the entire field of developmental neurobiology cannot be overstated. Following a brief introduction to the biology of neurotrophins and their receptors, this review will focus on oncogenic Trk in human malignant disorders, discuss putative tumorigenic involvement of Trk family members in the childhood malignancy neuroblastoma, and point out potential neurotrophin-based treatment modalities for this and other neuroendocrine tumors. |
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