Neuropathogenesis of AIDS |
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| Affiliation: | 1. School of Environmental and Municipal Engineering, Xi''an University of Architecture and Technology, No.13 Yanta road, Xi''an 710055, P.R. China;2. Key Lab of Northwest Water Resource, Environment and Ecology, MOE, Xi''an University of Architecture and Technology, No.13 Yanta road, Xi''an 710055, P.R. China |
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| Abstract: | Neurological disease directly attributable to HIV-1 infection (HIV dementia) is one of the most frequent disorders in persons with AIDS. HIV-1 dementia is associated with neuronal loss, but occurs in the absence of direct viral infection of neurons, suggesting that neurological damage occurs by an indirect mechanism. Recent studies have identified a number of candidate HIV-1 neurotoxins that may cause neuronal damage through common pathways involving the induction of oxidative stress and excitotoxicity. These findings suggest new therapeutic approaches to the prevention and treatment of HIV-1-induced neurological disease. |
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