Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes |
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| Affiliation: | 1. Fibrosis Biology and Biomarkers, Nordic Bioscience, Herlev, Denmark;2. Disease Systems Immunology, Technical University of Denmark, Kgs. Lyngby, Denmark;3. Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA;4. Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, MS, USA;1. Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS;2. Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, MS;1. Department of Mechanical Engineering, The University of Texas at San Antonio, USA;2. Joint Biomedical Engineering Program, UTSA-UTHSCSA, USA;3. San Antonio Cardiovascular Proteomics Center, USA;4. Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, USA;5. Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, USA;6. Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, USA;2. Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, MS, United States |
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| Abstract: | Cardiovascular Disease (CVD) is the most common cause of death in industrialized countries, and myocardial infarction (MI) is a major CVD with significant morbidity and mortality. Following MI, the left ventricle (LV) undergoes a wound healing response to ischemia that results in extracellular matrix (ECM) scar formation to replace necrotic myocytes. While ECM accumulation following MI is termed cardiac fibrosis, this is a generic term that does not differentiate between ECM accumulation that occurs in the infarct region to form a scar that is structurally necessary to preserve left ventricle (LV) wall integrity and ECM accumulation that increases LV wall stiffness to exacerbate dilation and stimulate the progression to heart failure. This review focuses on post-MI LV ECM remodeling, targeting the discussion on ECM biomarkers that could be useful for predicting MI outcomes. |
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