Regulation of oxidative activity and delta psi of liver mitochondria of active and hibernating gophers. The role of phospholipase A2. |
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| Authors: | N N Brustovetsky M V Egorova E I Mayevsky |
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| Affiliation: | Institute of Theoretical and Experimental Biophysics, U.S.S.R. Academy of Sciences, Pushchino, Moscow Region. |
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| Abstract: | 1. In the present work the initially lowered oxidase activity of liver mitochondria of hibernating gophers is shown to increase upon Ca(2+)-loading, after freezing-thawing repeated three times and after swelling in a medium containing potassium acetate as well as in a hypotonic sucrose medium. 2. In all cases the inhibition of phospholipase A2 hindered the increase of the oxidase activity of mitochondria. 3. Mitochondria of hibernating gophers have a lowered delta psi in comparison with active animals, which is restored in the hypotonic medium. |
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