Enhancement of Lanthanum (III) on Sodium Currents in Acutely Isolated Hippocampal CA1 Neurons of Rat |
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| Authors: | Huizhi Du Pin Yang |
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| Institution: | (1) Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Wucheng Road 92, 030006 Taiyuan, People’s Republic of China |
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| Abstract: | The effects of lanthanum (III) (La3+) on voltage-gated sodium channel currents (I
Na) in freshly dissociated rat hippocampal CA1 neurons were studied using the whole-cell patch clamp techniques. La3+ reversibly enhanced I
Na in a concentration- and voltage-dependent manner. The 50% enhancement concentration (EC50) of La3+ on I
Na was 9.93 μM. In addition, 10 μM La3+ shifted the steady state activation curve of I
Na towards positive potential and the steady state inactivation curve towards negative potential without changing the slope
factor. These results indicated that La3+ could increase the amplitudes of I
Na and change the activation and inactivation courses of I
Na even in very low concentration. |
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| Keywords: | Lanthanum (III) Sodium current Hippocampal CA1 neurons The whole-cell patch clamp techniques |
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