| 凋亡诱导因子AIF在肝癌组织中的表达及临床意义* |
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| 引用本文： | 郭晓东杨永平楼敏熊璐曲建慧王春平陆荫英周霖常秀娟,苏淑慧冯永毅.凋亡诱导因子AIF在肝癌组织中的表达及临床意义*[J].现代生物医学进展,2011,11(3):502-504. |
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| 作者姓名： | 郭晓东杨永平楼敏熊璐曲建慧王春平陆荫英周霖常秀娟 苏淑慧冯永毅 |
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| 作者单位： | 北京市解放军第302医院,北京,100039 |
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| 摘 要： | 目的:探讨凋亡诱导因子(AIF)在肝细胞癌组织中的表达及其临床意义。方法:采用免疫组织化学Envision法检测75例肝细胞癌组织及其相应癌旁肝组织、30例正常肝组织中AIF的表达,并分析其表达与肝细胞癌临床病理因素的相关性。结果:肝癌组织中AIF阳性表达率明显高于癌旁组织及正常肝组织,差异均具有统计学意义(P<0.01)。AIF在肝癌组织中的表达仅与病理分级密切相关(P<0.01),而与年龄、性别、肿瘤大小、临床分期、肿瘤数目、有无肿瘤包膜和有无淋巴结转移、有无门静脉癌栓均无关。结论:AIF表达可能参与了肝癌的发生和发展过程。
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| 关 键 词： | 肝细胞癌 凋亡诱导因子 免疫组织化学 |
Expression of Apoptosis Inducing Factor in Hepatocellular Carcinoma and
Its Clinical Signficance |
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| GUO Xiao-dong,YANG Yong-ping,LOU Min,XIONG Lu,QU Jian-hui,WANG Chun-ping,LU Yin-ying,ZHOU Lin,CHANG Xiu-juan,SU Shu-hui,FENG Yong-yi.Expression of Apoptosis Inducing Factor in Hepatocellular Carcinoma and
Its Clinical Signficance[J].Progress in Modern Biomedicine,2011,11(3):502-504. |
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| Authors: | GUO Xiao-dong YANG Yong-ping LOU Min XIONG Lu QU Jian-hui WANG Chun-ping LU Yin-ying ZHOU Lin CHANG Xiu-juan SU Shu-hui FENG Yong-yi |
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| Institution: | GUO Xiao-dong,YANG Yong-ping,LOU Min,XIONG Lu,QU Jian-hui,WANG Chun-ping,LU Yin-ying,ZHOU Lin,CHANG Xiu-juan,SU Shu-hui,FENG Yong-yi(302 hospital of PLA,Beijing China,100039) |
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| Abstract: | Objective:To investigate the expression and clinical signficance of AIF in hepatocellular carcinoma tissue.Methods:The expression of AIF protein was detected with immunohistochemical EnVision plus non-hiotin technique in 75 cases of hepatocellular carcinoma and pericarcinoma tissues,30 cases of norma1 tissues.Results:The positive expression rates of AIF protein in hepatocellular carcinoma were significantly higher than that in pericarcinoma tissues and norma1 tissues(P<0.05).The expression of AIF were posit... |
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| Keywords: | Hepatocellular carcinoma Apoptosis inducing factor Immunohistochemistry |
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