| 红霉素对慢性阻塞性肺疾病大鼠ICAM-1、MMP-9的表达影响 |
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| 引用本文： | 黄玲媚罗百灵,陈红梅.红霉素对慢性阻塞性肺疾病大鼠ICAM-1、MMP-9的表达影响[J].现代生物医学进展,2011,11(3):497-501. |
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| 作者姓名： | 黄玲媚罗百灵 陈红梅 |
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| 作者单位： | 中南大学湘雅医院呼吸内科,湖南,长沙,410008 |
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| 摘 要： | 目的:观察慢性阻塞性肺疾病(COPD)大鼠肺组织中ICAM-1及MMP-9的表达及红霉素的干预作用。方法:复制COPD大鼠模型,并用红霉素干预,收集支气管肺泡灌洗液行细胞学计数和分类检查;采用HE染色观察病理形态变化;免疫组化法检测大鼠支气管肺组织ICAM-1、MMP-9的表达。结果:与模型组比较,干预组支气管肺组织中ICAM-1、MMP-9表达显著降低;模型组中ICAM-1、MMP-9的表达与BALF中白细胞总数及中性粒细胞数成正相关;ICAM-1与MMP-9的表达成正相关。结论:COPD大鼠肺组织中的ICAM-1、MMP-9表达明显升高,可能与COPD的发病机制有关;红霉素可降低ICAM-1、MMP-9的表达,可能是红霉素在COPD中抗炎症反应的作用机制之一。
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| 关 键 词： | 红霉素 慢性阻塞性肺疾病 ICAM-1 MMP-9 |
Effect of Erythromycin on Expressions of ICAM-1 and MMP-9
in Rats with COPD |
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| HUANG ling-mei,LUO Bai-ling,CHEN hong-mei.Effect of Erythromycin on Expressions of ICAM-1 and MMP-9
in Rats with COPD[J].Progress in Modern Biomedicine,2011,11(3):497-501. |
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| Authors: | HUANG ling-mei LUO Bai-ling CHEN hong-mei |
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| Institution: | HUANG ling-mei,LUO Bai-ling,CHEN hong-mei(Department of Respiratory Medicine,Xiangya Hospital of Central South University,Changsha 410008,China) |
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| Abstract: | Objective:To explore the role of ICAM-1 and MMP-9 in the pathogenesis of COPD,and to study the effects of ery-thromycin(EM)on lung ICAM-1 and MMP-9 expression in vivo experiment of COPD rats.Methods:We established COPD rat models and use Erythromycin to interven.BALF were collected to count the total and differential cell counts.The pathological changes were observed.The expressions of ICAM-1 and MMP-9 were detected by immunohistochemistry.Results:Compared to the COPD group,the expression of ICAM-1 and MMP-... |
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| Keywords: | ICAM-1 MMP-9 |
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