The enzymatic synthesis of ATP analogues. |
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| Authors: | D Johnson M MacCoss S Narindrasorasak |
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| Affiliation: | 1. Department of Biochemistry University of Alberta Edmonton, Alberta T6G 2H7, Canada;2. Department of Chemistry University of Alberta Edmonton, Alberta T6G 2H7, Canada |
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| Abstract: | The enzymatic synthesis of selected adenosine 5′-triphosphate analogues from their respective 5′-monosphosphates has been achieved using phosphoenolpyruvate synthetase. Adenosine 5′-monophosphate analogues altered at positions 1,6,7,8 or 9 of the purine ring, or at the ribose 2′- or 3′-positions are substrates with 30% conversion to the nucleoside 5′-triphosphate. |
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