A targeted lipidomics approach to the study of eicosanoid release in synovial joints |
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| Authors: | Janny C de Grauw Chris HA van de Lest Paul René van Weeren |
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| Affiliation: | (1) Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 114, 3584, CM, Utrecht, The Netherlands;(2) Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584, CM, Utrecht, The Netherlands |
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| Abstract: | Introduction Articular tissues are capable of producing a range of eicosanoid mediators, each of which has individual biological effects and may be affected by anti-inflammatory treatment. We set out to develop and evaluate a high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) approach for the simultaneous analysis of multiple eicosanoid lipid mediators in equine synovial fluid (SF), and to illustrate its use for investigation of the in vivo effects of non-steroidal anti-inflammatory drug (NSAID) treatment. |
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