Evolutionary ontogenetic aspects of pathogenetics of chronic human diseases |
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Authors: | V P Puzyrev A N Kucher |
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Institution: | 1.Research Institute of Medical Genetics, Siberian Branch,Russian Academy of Medical Sciences,Tomsk,Russia;2.Department of Medical Genetics,Siberian State Medical University,Tomsk,Russia |
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Abstract: | This article is a review of scientific publications, in which issues of pathogenetics of multifactorial diseases (MFDs) are
considered from the viewpoint of evolution and ontogeny. Concepts explaining significance of evolutionary processes in the
formation of genetic architecture of human chronic diseases (“thrifty” genomes and phenotypes, “drifty genes,” decanalization)
are analyzed. The roles of natural selection and genetic drift in the formation of hereditary diversity of genes for susceptibility
to MFDs are considered. The modern concept of “disease ontogeny” (somatic mosaicism, loss of heterozygosity, paradominant
inheritance, epigenetic variability) is discussed. It is demonstrated that the evolutionary and ontogenetic approaches to
analysis of genimuc and other “-omic” data are essential for understanding the biology of diseases. |
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Keywords: | |
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