Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines |
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| Authors: | Yihong CS Lu Christopher H Evans Alan J Grodzinsky |
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| Affiliation: | (1) Department of Biological Engineering, MIT, 500 Technology Square NE47-377, Cambridge, MA 02139, USA;(2) Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RN-115, Boston, MA 02215, USA;(3) Departments of Electrical Engineering and Computer Science and Mechanical Engineering, MIT, 500 Technology Square NE47-377, Cambridge, MA 02139, USA |
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| Abstract: | Introduction Traumatic joint injury damages cartilage and causes adjacent joint tissues to release inflammatory cytokines, increasing the risk of developing osteoarthritis. The main objective of this study was to determine whether the combined catabolic effects of mechanical injury, tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)/soluble IL-6 receptor (sIL-6R) on cartilage could be abolished by short-term treatment with glucocorticoids such as dexamethasone. |
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