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Characterization of the Receptor-binding Domain of Ebola Glycoprotein in Viral Entry |
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| Authors: | Jizhen Wang Balaji Manicassamy Michael Caffrey Lijun Rong |
| Institution: | Jizhen Wang1,Balaji Manicassamy1,3,Michael Caffrey2 and Lijun Rong1**(1.Department of Microbiology and Immunology,College of Medicine,University of Illinois at Chicago,Chicago,IL 60612,USA,2.Department of Biochemistry and Molecular Genetics,IL 60607 USA,3.Current address for B.M:Department of Microbiology,Mount Sinai School of Medicine,1 Gustave L.Levy Place,Box 1124 New York,NY 10029,USA) |
| Abstract: | Ebola virus infection causes severe hemorrhagic fever in human and non-human primates with high mortality.Viral entry/infection is initiated by binding of glycoprotein GP protein on Ebola virion to host cells,followed by fusion of virus-cell membrane also mediated by GP.Using an human immunodeficiency virus(HIV)-based pseudotyping system,the roles of 41 Ebola GP1 residues in the receptor-binding domain in viral entry were studied by alanine scanning substitutions.We identified that four residues appear to b... |
| Keywords: | Receptor-binding domain Ebola virus Glycoprotein Viral Entry |
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