Host Cell Protein C9orf9 Promotes Viral Proliferation via Interaction with HSV-1 UL25 Protein |
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| Authors: | Ying Zhang Yan-mei Li Long-ding Liu Li Jiang Ma Ji Rui-ju Jiang Lei Guo Yun Liao Qi-han Li |
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| Institution: | Ying Zhang,Yan-mei Li,Long-ding Liu,Li Jiang,Ma Ji,Rui-ju Jiang,Lei Guo,Yun Liao and Qi-han Li**(Institute of Medical Biology,Chinese Academy of Medicine Science & Peking Union Medical College,Kunming 650118,China) |
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| Abstract: | In light of the scarcity of reports on the interaction between HSV-1 nucleocapsid protein UL25 and its host cell proteins,the purpose of this study is to use yeast two-hybrid screening to search for cellular proteins that can interact with the UL25 protein.C9orf69,a protein of unknown function was identified.The interaction between the two proteins under physiological conditions was also confirmed by biological experiments including co-localization by fluorescence and immunoprecipitation.A preliminary study... |
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| Keywords: | Herpes simplex virus(HSV-1) UL25 C9orf69 Proliferation |
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