The effect of an antigenic stimulation on proliferative response in athymic mice |
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| Authors: | P ?íma M Bilej F Ková?? V Větvi?ka M Holub |
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| Institution: | (1) Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20 Prague 4, Czechoslovakia;(2) School of Veterinary Medicine, Brno, Czechoslovakia;(3) Institute of Clinical and Experimental Medicine, Prague 4, Czechoslovakia |
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| Abstract: | The proliferation activity of the main cellular categories of bone marrow after infusion of3H-thymidine was studied in nu/nu and +/+ 1-month- and 3-month-old BALB/c mice in comparison with lymphoid cells in the spleen and mesenteric lymph nodes. The stem cell defect in nu/nu mouse bone
marrow is compensated by an, increased proliferation in myeloid series and in agranulocytes. The increase of proliferation
activity among lymphoid cells in peripheral lymphoid organs was observed only in the 3-month-old mice with a delay in the
nudes. |
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