PVA颗粒与中药白芨栓塞犬子宫动脉的对比研究

目的:研究PVA微粒、中药白芨颗粒栓塞犬子宫动脉所引起的子宫病理变化,观察两者之间对子宫影响有无差别;探讨中药白芨作为血管栓塞剂的有效性、安全性及相关特性。方法:先结扎8例犬双侧子宫动脉,病理证实子宫组织无坏死。然后采用Seldinger技术,对16例犬进行选择性子宫动脉栓塞。分别向子宫动脉注入PVA微粒、中药白芨颗粒阻断供血,观察子宫病理变化。将病理结果予以定量,综合评价脏器损伤。结果:双侧子宫动脉栓塞后,各栓塞组之间样本均数两两比较,均为P>0.05,即三种处理对于子宫组织损伤无统计学差异。白芨主要栓塞末梢小动脉,栓塞牢靠,不易形成侧支循环,未出现细胞坏死。结论:选择上述栓塞剂,对子宫组织损伤效果一致,中药白芨颗粒具有良好的血管栓塞作用和载体特性,使用方便、安全,是一种较理想的末梢型血管栓塞剂。

Comparative Study of Canine Uterine Artery Embolization with PVA Particles and Bletilla Striata of Chinese Herbal Medicine

Objective:To compare the pathological changes of uterine artery embolization with PVA particles and Bletilla Striata, and evaluate the validity,security and correlative characteristics of Bletilla Striata as a vascular embolization agent.Methods:Uterine tis- sues were confirmed no necrosis by pathology after bilateral uterine artery ligation.Adopting the Seldinger technique,embolic materials were infused into the bilateral uterine arteries respectively,and pathological changes of the uterine tissues were observed.The pathologi- cal results were quantitatively analyzed alone with integral weighted method,and the damaged organs were evaluated.Results:The sam- ple means were compared between ligated group and embolized groups,P>0.05,and which means there was no difference of uterine tis- sues changes after all treatments.The Bletilla Striata mainly embolized peripheral arteries,and there were few collateral circulations and no cytonecrosis.Conclusions:It suggests that Bletilla Striata and PVA particles are equivalent in damaged effects.Bletilla Striata is safe and effective in vascular embolization with characteristic of carrier,and it is a potential peripheral embolization agent.