An autoimmune diabetes locus (Idd21) on mouse Chromosome 18 |
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| Authors: | Hall Richard J. Hollis-Moffatt Jade E. Merriman Marilyn E. Green Rachel A. Baker David Merriman Tony R. |
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| Affiliation: | (1) Department of Biochemistry, University of Otago, Dunedin, New Zealand;(2) Department of Neuroinflammation, Institute of Neurology, University College London, London, UK |
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| Abstract: | Twenty-four named Idd loci that contribute to the development of autoimmune diabetes in the nonobese diabetic (NOD) mouse have been mapped by linkage and congenic analysis. Previously, meta-analysis of genome-wide linkage scans supported the existence of a locus for susceptibility to autoimmune phenotypes on rodent Chromosome (Chr) 18, in a position orthologous to the human type 1 diabetes susceptibility locus IDDM6 (human Chr 18q12-q23). However, an autoimmune diabetes susceptibility locus has not previously been reported on mouse Chr 18. In this study, we demonstrate linkage of the majority of mouse Chr 18 to diabetes in a (ABH × NOD)F1 × NOD backcross. Congenic analysis, introgressing at least 92% of Biozzi ABH Chr 18 onto the NOD background, confirmed the presence of a diabetes locus. The chromosome substitution strain (NOD.ABH-Chr18) had reduced diabetes incidence compared with NOD mice (P < 0.0001). We have named the Chr 18 diabetes locus Idd21. |
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