Induction of DNA double-strand breaks by X-rays in a radiosensitive strain of the yeast Saccharomyces cerevisiae |
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Authors: | Karen S.Y. Ho |
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Affiliation: | Donner Laboratory, University of California, Berkeley, California 94720, U.S.A. |
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Abstract: | Sedimentation profiles for chromosomal DNA from unirradiated and X-irradiated yeast cells of wild type and rad 52 strains are presented. These profiles indicate that, whereas wild type strains rejoin DNA double-strand breaks, rad 52 strains apparently do not. These data suggest that the rad 52 mutant lacks a repair system for X-ray induced damage and are consistent with the proposal that an unrepaired chromosome break leads to reproductive cell death. |
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Keywords: | EMS ethyl methanosulfonate |
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