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Radioimmunoassay for plasma betamethasone 17-benzoate. |
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| Authors: | A Mizuchi N Okada Z Henmi Y Miyachi |
| Institution: | Department of Biochemical Pharmacology, Institute of Biological Science, Mitsui Pharmaceuticals Inc., 1900-1 Togo, Mobara-shi, Chiba-ken, Japan |
| Abstract: | A sensitive radioimmunoassay for plasma betamethasone 17-benzoate has been developed. The antiserum used was obtained by immunizing rabbits with betamethasone 17-benzoate-21-hemisuccinate-bovine-serum-albumin conjugate. All of the endogenous steroids tested cross reacted less than 0.10%. A standard curve was established with a useful range from 0.05-5 ng. Reliability criteria were satisfactory. Measurement of plasma concentrations of betamethasone 17-benzoate was performed in patients and in rabbits following occlusive dressing of betamethasone 17-benzoate cream and gel base. |
| Keywords: | Betamethasone 17-benzoate 9α-fluoro-11β 17 21-trihydroxy-16β-methylpregna-1 4-diene-3 20-dione 17-benzoate Betamethasone 17-valerate 9α-fluoro-11β 17 21-trihydroxy-16β-methylpregna-1 4-diene-3 20-dione 17-valerate Betamethasone 9α-fluoro-11β 17 21-trihydroxy-16β-methyl-pregna-1 4-diene-3 20-dione Dexamethasone 9α-fluoro-11β 17 21-trihydroxy-16α-methyl-pregna-1 4-diene-3 20-dione Cortisol 11β 17 21-trihydroxy-4-pregnene-3 20-dione Corticosterone 11β 21-dihydroxy-4-pregnene-3 20-dione Progesterone 4-pregnene-3 20-dione Testosterone 17β-hydroxy-4-androstene-3-one Estradiol-17β 1 3 5(10)-estratriene-3 17β-diol |
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