阴道微生态平衡与念珠菌性阴道炎研究

目的应用延华乳酸杆菌胶囊对念珠菌性阴道炎病人进行治疗，探讨阴道微生态平衡与念珠菌阴道炎的关系。方法2007年4月至2008年3月，来自我院妇科门诊确诊为念珠菌阴道炎的病人，患者年龄在17—58岁。结果对临床确诊为念珠菌性阴道炎病人进行阴道乳酸杆菌计数，之后随机分成A（205人）、B（198人）2组，分别采用微生态疗法和传统法进行治疗，并且对治愈的病人通过阴道分泌物干片法进行微生态情况的观察和念珠菌培养鉴定法来观察念珠菌性阴道炎的复发情况。结果A组病人治疗后乳酸杆菌计数：1＋者为17％（35／205）、≥2＋者为72％（148／205）和0者为11％（22／205）；B组病人则分别为52％（104／198）、20％（40／198）和27％（54／198）；念珠菌阴道炎复发率A组为10％（21／205），B组为43％（86／198）；组间比较乳酸杆菌计数及阴道炎复发率差异均有显著性（P〈0．05）。结论阴道微生态的平衡与念珠菌性阴道炎密切相关，调整妇女阴道微生态的平衡可大大降低阴道炎的复发和提高治疗效果。

Vaginal microecological balance and vulvovaginal candidosis

Objective To investigate the relation between vaginal microecological balance and vulvovaginal candidosis （VVC）. Method Counting of vaginal laetobaeilli was performed in women aged 17 - 58 diagnosed as VVC during April 2007 - March 2008. The patients were then divided randomly into Group A （205） and B （198） and treated with microecological and traditional therapies respectively. The microeeologieal status and recurrence of VVC were observed. Resuits The counting of laetobacilli showed that ＂1 ＋ ＂ accounted for 17% （ 35/205 ） in group A vs. 52% （ 104/198 ） in group B, ＂≥2 ＋ ＂ accounted for 72% （148/205） in group A vs. 20% （40/198） in group B ,while ＂zero＂ accounted for 11% （ 22/205 ） in group A vs. 27% （ 54/198 ） in group B. There were significant differenees in the eountings of laetobaeilli and recurrence rates between the two groups （ P 〈 0.05 ）. Conclusion Vaginal microeeologieal balance is closely related to VVC. Recurrence rate of VVC can be significantly reduced and therapeutic effect be improved by regulating the vaginal microecologica balance.