| 乙型肝炎IgA类HBsAg循环免疫复合物的检测及意义 |
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| 引用本文： | 彭宣宪,方亮,谢天益,李兆瑞,李建生.乙型肝炎IgA类HBsAg循环免疫复合物的检测及意义[J].Virologica Sinica,1990(1). |
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| 作者姓名： | 彭宣宪 方亮 谢天益 李兆瑞 李建生 |
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| 作者单位： | 江西大学生物系微生物学教研室，西安医科大学病毒学研究室，西安医科大学病毒学研究室，西安市传染病医院，西安市传染病医院 南昌 330047，西安 710061，西安 710061，西安 710061，西安 710061 |
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| 摘 要： | 本文报道用捕捉法ELISA检测各型乙肝IgA型HBsAg循环免疫复合物。结果表明,慢性乙肝IgA型HBsAg循环免疫复合物检出率显著高于急性乙肝;在慢性乙肝中,IgA型HBsAg循环免疫复合物的出现与HBVe系统关系密切,主要存在于HBeAg阳性血清中,并与HBeAg滴度有关。故IgA型HBsAg循环免疫复合物可作为HBV慢性感染的血清诊断标志之一;也可作为反映HBV在增殖并有传播危险的标志之一。
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| 关 键 词： | 酶联免疫吸附试验 乙型病毒性肝炎 循环免疫复合物 免疫球蛋白A 乙型肝炎病毒表面抗原 |
Detection and Significance of Circulating HBsAg/IgA Immune Complexes in Patients with Hepatitis B |
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| Peng Xuan-xian et al.Detection and Significance of Circulating HBsAg/IgA Immune Complexes in Patients with Hepatitis B[J].中国病毒学(英文版),1990(1). |
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| Authors: | Peng Xuan-xian |
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| Abstract: | Circulating HBsAg/IgA immune complexes were detected in different groups of hepatitis B patiens by ACCA-ELISA(antibody class capture assay ELISA). The positive rates of chronic hepatitis B were significantly higher than those of acute hepatitis B, The occuranceof circulating HBsAg/IgA immune complexes was closely associated with HBV e system and the titer of HBeAg. These results seem to indicate that the immune response to form circulating HBsAg/IgA immune complexes may be a valuable marker of chronic infection of HBV; and it may also be considered as a marker of replication of HBV. |
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| Keywords: | ELISA Hepatitis B Circulating immune complex IgA HBsAg |
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