Hormonal Regulation of Activities of Digestive Enzymes in Small Intestine of Young Rats at Protein Deficiency in Nutrition of Female Rats at Lactation Period

It is revealed that administration of exogenous dexamethasone and thyroxin to the 7-8-day old rat pups produces different effect on activity and ratio of membrane and soluble forms of digestive enzymes (lactase, saccharase, maltase, alkaline phosphatase, aminopeptidase M, and glycyl-L-leucine dipeptidase) in jejunum and ileum of animals, whose mothers received different rations during lactation: the standard (control) and low-protein (experiment) ones. Disturbances of the hormonal regulation of the activity and the ratio of membrane and soluble forms of the digestive enzymes in small intestine in early ontogenesis consisted in that the effect of hormones was much less pronounced in the rat pups of the experimental group. An increase of the portion of the soluble form of the enzymes was also revealed. These results indicate a possibility of retardation of maturation of the intestinal digestive enzymes. The most significant difference of these effects in animals of the experimental and control groups was observed for saccharase, maltase, and peptidases.