Synthesis of C-2 and C-4 deuterium-labeled estradiol-17 beta |
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Authors: | P Ferraboschi M Ravasi E Santaniello |
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Institution: | 4. Istituto di Endocrinologia, Facoltà di Farmacia, Via A. Del Sarto, 21 Università di Milano, Italy |
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Abstract: | Estradiol-17 beta labeled with deuterium in the positions 2 or 4 can be prepared from 2-chloromercurio-1,3,5(10)-estratriene-3,17 beta-diol 3-methyl ether 17-acetate or 4-chloromercurio-1,3,5(10)-estratriene-3,17 beta-diol, respectively, in refluxing CH3COO(2)H/(2)H2O. The same reaction performed on 4-acetoxymercurio-1,3,5(10)-estratriene-3,17 beta-diol afforded 2,4-dideuterio-estradiol-17 beta in good yields. |
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