| Complexin在囊泡运输中的作用 |
| |
| 引用本文： | 李小红,龚吉红,林显光,阳小飞.Complexin在囊泡运输中的作用[J].生物化学与生物物理进展,2015,42(5):403-409. |
| |
| 作者姓名： | 李小红 龚吉红 林显光 阳小飞 |
| |
| 作者单位： | 中南民族大学生物医学工程学院，脑认知国家民委重点实验室、膜离子通道与药物研发实验室，武汉 430074,中南民族大学生物医学工程学院，脑认知国家民委重点实验室、膜离子通道与药物研发实验室，武汉 430074,中南民族大学生物医学工程学院，脑认知国家民委重点实验室、膜离子通道与药物研发实验室，武汉 430074,中南民族大学生物医学工程学院，脑认知国家民委重点实验室、膜离子通道与药物研发实验室，武汉 430074 |
| |
| 基金项目： | 国家自然科学基金资助项目(31300892) |
| |
| 摘 要： | 神经递质释放对维持生物体正常的生命活动有着重要的意义,它是由囊泡运输介导完成的.神经元细胞中囊泡运输涉及许多蛋白质间的相互作用,共同调控这一复杂的过程,可溶性小分子蛋白Complexin(Cpx)在这一过程中起着重要的作用,它同时具有抑制囊泡自发发放和促进囊泡诱发发放的功能.本文综合国内外近20年的研究,着重介绍了Cpx蛋白各部分结构域的功能,及其与一些囊泡分泌相关蛋白,如SNARE复合体、Synaptotagmin(Syt),间的相互作用机制及其最新进展.
|
| 关 键 词： | 囊泡运输，Complexin，SNARE，Synaptotagmin |
| 收稿时间： | 2014/11/10 0:00:00 |
| 修稿时间： | 3/1/2015 12:00:00 AM |
The Function of Complexin in Vesicle Transmission |
| |
| LI Xiao-Hong,GONG Ji-Hong,LIN XianGuang and YANG Xiao-Fei.The Function of Complexin in Vesicle Transmission[J].Progress In Biochemistry and Biophysics,2015,42(5):403-409. |
| |
| Authors: | LI Xiao-Hong GONG Ji-Hong LIN XianGuang and YANG Xiao-Fei |
| |
| Institution: | Key Laboratory of Cognitive Science, Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering,South-Central University for Nationalities, Wuhan 430074, China,Key Laboratory of Cognitive Science, Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering,South-Central University for Nationalities, Wuhan 430074, China,Key Laboratory of Cognitive Science, Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering,South-Central University for Nationalities, Wuhan 430074, China and Key Laboratory of Cognitive Science, Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering,South-Central University for Nationalities, Wuhan 430074, China |
| |
| Abstract: | Neurotransmitter release is critical for maintaining normal organism function, it is mediated by the vesicle transportation. A bundle of proteins regulate the complicated neuronal vesicle transmission by interacting with each other. The small soluble protein Complexin (Cpx) plays an important role that can both inhibit spontaneous vesicle fusion and promote evoked Ca2+-dependent neurotransmitter release. In this review, we highlight the recent advances in the function of each domain of Cpx and the mechanisms of interacting with other vesicle exocytosis associated proteins such as SNARE complex and synaptotagmin. |
| |
| Keywords: | vesicle transmission complexin SNARE synaptotagmin |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
| 点击此处可从《生物化学与生物物理进展》下载免费的PDF全文 |
|
