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Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors |
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| Authors: | Ogawa Anthony K Willoughby Chris A Bergeron Raynald Ellsworth Kenneth P Geissler Wayne M Myers Robert W Yao Jun Harris Georgianna Chapman Kevin T |
| Affiliation: | Department of Basic Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. anthony_ogawa@merck.com |
| Abstract: | The synthesis of a series of novel dihdyropyridine diacid glycogen phosphorylase inhibitors is presented. SAR and functional assay data are discussed, along with the effect of a single inhibitor on blood glucose in a diabetic animal model. |
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