Neonatal Handling, Sweet Food Ingestion and Ectonucleotidase Activities in Nucleus Accumbens at Different Ages |
| |
Authors: | P P Silveira G Cognato L M Crema F Q Pederiva C D Bonan J J Sarkis A B Lucion C Dalmaz |
| |
Institution: | (1) PPG Neurociências e Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, UFRGS, Porto Alegre, RS, Brazil;(2) Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 32, 90035-003 Porto Alegre, RS, Brazil;(3) PPG Neurociências e Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, UFRGS, Porto Alegre, RS, Brazil;(4) Departamento de Ciências Fisiológicas, Faculdade de Biociências, PUCRS, Porto Alegre, RS, Brazil |
| |
Abstract: | Neonatal handled rats ingest more sweet food than non-handled ones, but it was documented only after puberty. Here, we studied the purinergic system in the nucleus accumbens, a possible target for the alteration in the preference for palatable food. We measured the ATP, ADP and AMP hydrolysis mediated by ectonucleotidases in synaptosomes of the nucleus accumbens in periadolescent and adult rats from different neonatal environments: non-handled and handled (10 min/day, first 10 days of life). Before adolescence, we found a decreased ingestion of sweet food in the neonatally handled group, with no effect on ATP, ADP or AMP hydrolysis. In adults, we found a greater ingestion of sweet food in the neonatally handled group, with no effect on ATPase or ADPase activities, but a decreased AMP hydrolysis. The nucleus accumbens is a site of intensive interaction between the adenosinergic and dopaminergic systems. Therefore, adenosine may modulate accumbens’ dopamine neurotransmission differently in neonatally handled rats. |
| |
Keywords: | Neonatal handling Adenosine Nucleus accumbens Dopamine ATPase– ADPase activities 5′ -nucleotidase activity |
本文献已被 PubMed SpringerLink 等数据库收录! |
|