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Transformation and Productive Infection of Human Osteosarcoma Cells by a Feline Sarcoma Virus |
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| Authors: | ROBERT M MCALLISTER JEAN E FILBERT MARGERY O NICOLSON ROBERT W RONGEY MURRAY B GARDNER RAYMOND V GILDEN ROBERT J HUEBNER |
| Institution: | 1.Department of Pediatrics,University of Southern California School of Medicine, Childrens Hospital of Los Angeles,Terminal Annex, Los Angeles;2.Department of Pathology,University of Southern California School of Medicine,Los Angeles;3.Flow Laboratories Incorporated,Rockville;4.Viral Carcinogenesis Branch,National Cancer Institute, National Institutes of Health,Bethesda |
| Abstract: | FELINE sarcoma virus (FSV) transforms human embryo cells in vitro1; it therefore seemed interesting to determine whether this virus could transform human osteosarcoma cells. Defective Moloney sarcoma virus genome can be rescued from non-producer hamster tumour cells by feline leukaemia virus (FeLV)2 and because FSV stocks also contain excess FeLV (ref. 1 and unpublished observations of R. V. G.), it was hoped that human osteosarcoma cells transformed by FSV and co-infected with FeLV might yield a human sarcoma virus. |
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