Association of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children |
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Authors: | Sharp Elizabeth R Willberg Christian B Kuebler Peter J Abadi Jacob Fennelly Glenn J Dobroszycki Joanna Wiznia Andrew A Rosenberg Michael G Nixon Douglas F |
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Affiliation: | Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America. |
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Abstract: | BackgroundIn the USA, most HIV-1 infected children are on antiretroviral drug regimens, with many individuals surviving through adolescence and into adulthood. The course of HIV-1 infection in these children is variable, and understudied.Methodology/Principal FindingsWe determined whether qualitative differences in immune cell subsets could explain a slower disease course in long term survivors with no evidence of immune suppression (LTS-NS; CD4%≥25%) compared to those with severe immune suppression (LTS-SS; CD4%≤15%). Subjects in the LTS-NS group had significantly higher frequencies of naïve (CCR7+CD45RA+) and central memory (CCR7+CD45RA−) CD4+ T cells compared to LTS-SS subjects (p = 0.0005 and <0.0001, respectively). Subjects in the rapid progressing group had significantly higher levels of CD4+ TEMRA (CCR7−CD45RA+) cells compared to slow progressing subjects (p<0.0001).Conclusions/SignificanceRapid disease progression in vertical infection is associated with significantly higher levels of CD4+ TEMRA (CCR7−CD45RA+) cells. |
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